In April 10, 1428, a Christian leader named Nestorius was consecrated as bishop of Constantinople. Upon his coming to the office, Nestorius began attacking the term “Theotokos” (God-bearer) to describe the Virgin Mary. “It is impossible that God should be born of a woman,” he said, suggesting Christotokos (Christ-bearer) instead.
He did not deny Jesus’ nature as God but simply felt that the term challenged the reality of Christ’s human nature. The church of his day denounced him as a heretic.